Current criteria for AKI diagnosis Serum Creatinine Scr Increased UO <05ml/kg/h Risk creatinine x1.5 or GFR X6h decrease >.25% Urine output Increased creatinine x 2 U0<05ml/kg/h x 12h Injury or GFR250% Scr UO <05ml/kg/h x6h Increase creatinine x UO<0.3ml/kg/h or gfr dec>75% R( Increase creatinine x1.5 x 24 or >0.3mg/dI Failure or creatinine 2 4mg/dl anuria 12 h (Acute rise of 20.5 mg/dl) Uo≤0.5mkgh (II) Increase creatinine x2 x12h Loss Complete loss of renal function >4 w Increase creatinine x3 UO<3ml/kg/h F(nor creatinine 24mg/dIx24 hr or ESRD End stage renal disease (Acute rise of 20.5 mg/d) Anuria x 12 hrs RRT Started RIFLE criteria AKIN criteriaCurrent criteria for AKI diagnosis • Serum Creatinine • Urine output Scr Increased creatinine x1.5 or GFR decrease > 25% UO < 0.5ml/kg/h x 6 h Increased creatinine x 2 or GFR  ≥ 50% UO < 0.5ml/kg/h x 12 h RIFLE criteria AKIN criteria Scr Increase creatinine x1.5 Or >0.3mg/dl Increase creatinine x2 Increase creatinine x3 or creatinine 4mg/dl (Acute rise of 0.5 mg/dl) UO < 0.5ml/kg/h x 6 h UO< 0.5ml/kg/h x 12 h UO < .3ml/kg/h x 24 hr or Anuria x 12 hrs R (I) I (II) F (III) RRT started UO < 0.3ml/kg/h x 24 h or anuria x 12 h Increase creatinine x 3 or GFR dec > 75% or creatinine  4mg/dl (Acute rise of 0.5 mg/dl) Complete loss of renal function > 4 w End stage renal disease Risk Injury Failure Loss ESRD