aNgewandte Communications Nanomedicine Principal Candid candoxin: A 16-residue peptide Ligand binding CDX)that is derived from candoxin C. Zhan, B. Li, L Hu, X. Wei, L. Feng, binds with a high affinity to nicotinic W. Fu s W. Lux Candoxin which are highly expressed on the Micelle-Based Brain-Targeted Drug brain barrier In vivo biodistribution and Delivery Enabled by a Nicotine omplementary he anti-glioblastoma effect indicate the Acetylcholine Receptor Ligand Subunit (- Chem. Int. Ed. 2o11, 5o, 1-5 2011 Wiley-VCH Verlag GmbH& Co KGaA, Weinheim These are not the final page numbers axCommunications Nanomedicine C. Zhan, B. Li, L. Hu, X. Wei, L. Feng, W. Fu,* W. Lu* &&&& —&&&& Micelle-Based Brain-Targeted Drug Delivery Enabled by a Nicotine Acetylcholine Receptor Ligand Candid candoxin: A 16-residue peptide (CDX) that is derived from candoxin binds with a high affinity to nicotinic acetylcholine receptors (see picture), which are highly expressed on the blood– brain barrier. In vivo biodistribution and the anti-glioblastoma effect indicate the potential of CDX as a ligand to enable brain-targeted drug delivery. Angew. Chem. Int. Ed. 2011, 50, 1 – 5 2011 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim www.angewandte.org 5 These are not the final page numbers!