Antiviral Therapy-important notes 1. Virus replication is dependent to the host cells Antiviral must be selective for viral enzyme or protein, or inhibit virus-Specific process 2. Usually antivirals inhibit replication, dont kill virus Reliance on host immune response for ultimate virus elimination 3. High error rate of viral replication Rapid development of drug resistance Need to suppress virus replication rapidly and efficiently1. Virus replication is dependent to the host cells Antiviral must be selective for viral enzyme or protein, or inhibit virus-specific process 2. Usually antivirals inhibit replication, don’t kill virus Reliance on host immune response for ultimate virus elimination 3. High error rate of viral replication Rapid development of drug resistance Need to suppress virus replication rapidly and efficiently Antiviral Therapy – important notes