fibrosis Effects of deposition of fibrous tissue varies with deposited location. Interlobular fibrosis Portal and periportal deposition of fibrous tissue Intralobular fibrosis - Disse space deposition of fibrous tissue The deposition of fibrous tissue Zones 32 is hallmark of irreversible liver damageFibrosis: Effects of deposition of fibrous tissue varies with deposited location. Interlobular fibrosis -- : Portal and periportal deposition of fibrous tissue Intralobular fibrosis -- Disse space deposition of fibrous tissue. **The deposition of fibrous tissue is hallmark of irreversible liver damage. 21