Genomic Library Construction Overlapping clones: Random shearing Partial digests: not all sites are cut use 4-bp recognition(e.g, Sau 3A)or rare-cutting enzymes (notl; 8 bp recognition) SS SSSSS SsS s SS SSS SS SGenomic Library Construction • Overlapping clones: • Random shearing • Partial digests: not all sites are cut use 4-bp recognition (e.g., Sau 3A) or rare-cutting enzymes (notI; 8 bp recognition) S S S S S S S S S S S S S S S S S S S S S