Substrates of the five reactions catalyzed by pyruvate dehydrogenase complex are efficientl channeled The lipoamide group attached to e swings between E (accepting the electrons and acetyl group) and E, (giving away the electrons), passing the acetyl group to Coenzyme a on E The multienzyme complexes catalyzing the oxidative decarboxylation of a few different kinds of a-keto acids, pyruvate dehydrogenase complex, a ketoglutarate dehydrogenase complex and branched chain a-keto acid dehydrogenase complex show remarkable structure and function relatedness(all have identical E3, Similar El and E• Substrates of the five reactions catalyzed by pyruvate dehydrogenase complex are efficiently channeled : The lipoamide group attached to E2 swings between E1 (accepting the electrons and acetyl group) and E3 (giving away the electrons), passing the acetyl group to Coenzyme A on E2 • The multienzyme complexes catalyzing the oxidative decarboxylation of a few different kinds of a-keto acids, pyruvate dehydrogenase complex, a￾ketoglutarate dehydrogenase complex and branched chain a-keto acid dehydrogenase complex show remarkable structure and function relatedness (all have identical E3 , similar E1 and E2 )