Cinical manifestations Enzyme activity l: nervous system: agitation, excitation, restlessness, headache skin and mucosa: dry skin, shedding hair koilonychia atrophic glossitis angular cheilitis Immunity l: infection Pica like eating clay, lime and coal, crude rice ,etc Dysphagia(Plummer-Vinson syndrome)Clinical manifestations Enzyme activity ↓: nervous system: agitation,excitation,restlessness, headache skin and mucosa: dry skin,shedding hair, koilonychia atrophic glossitis angular cheilitis Immunity ↓:infection Pica ：like eating clay,lime and coal, crude rice ,etc. Dysphagia (Plummer-Vinson syndrome)