Positive vs negative control Mutate Regulatory EXample of regulatory protein is regulatory gene to lose present protein function Positive control Operon ON Activator Operon OFF Negative control Operon OFF Repressor Operon ONPositive vs negative control Regulatory protein is present Mutate regulatory gene to lose function Positive control Negative control Example of regulatory protein Operon ON Operon OFF Operon OFF Operon ON Activator Repressor