The discovery of H.pylori as a major cause for peptic ulcer It was Robin Warren,a pathologist working in Perth,who first noted that spiral bacteria colonized the lower part of the stomach(antrum)in about half of the patients from which he had taken biopsies.Crucially,he noted that inflammation of the mucosal lining of the stomach(gastritis)always appeared close to the location of the spiral bacteria.Intrigued by these findings,Barry Marshall,a young clinical fellow,teamed up with Warren (picture),and together they assayed stomach biopsies from 100 patients. The first time that Marshall and Warren presented their work at a national meeting in Australia,it was rejected outright.Whereas Warren was too shy to push their remarkable findings,Marshall had a missionary's zeal and vigorously defended their research.In order to convince the reluctant medical community of the robustness of their discovery,Marshall did the ultimate experiment.He drank a culture of H.pylori,developed acute gastritis and then successfully treated the illness with antibiotics. 99 It was Robin Warren, a pathologist working in Perth, who first noted that spiral bacteria colonized the lower part of the stomach (antrum) in about half of the patients from which he had taken biopsies. Crucially, he noted that inflammation of the mucosal lining of the stomach (gastritis) always appeared close to the location of the spiral bacteria. Intrigued by these findings, Barry Marshall, a young clinical fellow, teamed up with Warren (picture), and together they assayed stomach biopsies from 100 patients. The first time that Marshall and Warren presented their work at a national meeting in Australia, it was rejected outright. Whereas Warren was too shy to push their remarkable findings, Marshall had a missionary's zeal and vigorously defended their research. In order to convince the reluctant medical community of the robustness of their discovery, Marshall did the ultimate experiment. He drank a culture of H. pylori, developed acute gastritis and then successfully treated the illness with antibiotics. The discovery of H. pylori as a major cause for peptic ulcer