Disruption of the microbial cell membrane Essentially, affect cell membrane transportation in and out ncreases permeability of membrane External influences have greater effect Microbe death Y Detergent like: Polymyxin, Colistin Specific interfere with biosynthetic function of Cm novobiocin Y ionophores(cations ): Valinomycin-binds potassium ions Note: These agents are more toxic systemically than those agents that inhibit cell wall synthesis.Disruption of the microbial cell membrane • Essentially, affect cell membrane transportation in and out • Increases permeability of membrane – External influences have greater effect – Microbe death  Detergent like: Polymyxin, Colistin  Specific interfere with biosynthetic function of CM : novobiocin  Ionophores (cations): Valinomycin –binds potassium ions Note: These agents are more toxic systemically than those agents that inhibit cell wall synthesis