Image removed due to copyright considerations Hanahan Weinberg, Cell [20001 We know quite a lot about the signaling cascade that follows the initial biochemical event, leading to morphological changes, variations in various biochemical signals changes in gene expression and protein synthesis, but relatively little about how the initial event is transduced from physical force to biochemical reactionImage removed due to copyright considerations. Hanahan & Weinberg, Cell [2000] We know quite a lot about the signaling cascade that follows the initial biochemical event, leading to morphological changes, variations in various biochemical signals, changes in gene expression and protein synthesis, but relatively little about how the initial event is transduced from physical force to biochemical reaction