Transplantation Immunology CHAPTER 21 VISUALIZING CONCEPTS (b) First-set rejection (c)Second-set rejection fted epidermis Grafted epidermis Grafted epidermis Blood vessels Days 3-7: Revascularization Days 3-4: Cellular infiltration Days 7-10: Cellular infiltrate Days 5-6: Thrombosis and necrosis 吵 Necrotic tissue Days 12-14: Resolution Days 10-14: Thrombosis and necrosis Damaged blood vessels FIGURE 21-1 Schematic diagrams of the process of graft ac- 10-14 days.(c)Second-set rejection of an allograft begins within eptance and rejection. (a) Acceptance of an autograft is com- 3-4 days, with full rejection by 5-6 days. The cellular infiltrate that pleted within 12-14 days.(b) First-set rejection of an allograft invades an allograft(b, c)contains lymphocytes, phagocytes, and begins 7-10 days after grafting, with full rejection occurring by other inflammatory cells nin an inbred strain of mice, all animals are homozy. can accept grafts from either parent. Neither of the parental gous at each MHC locus. When mice from two different in- strains, however, can accept grafts from the F, offspring be- bred strains, with haplotypes b and k, for example, are mated, cause each parent lacks one of the F, haplotypes MHC inher all the Fi progeny inherit one haplotype from each parent(see itance in outbred populations is more complex, because the Figure 7-2a). These F1 offspring have the MHC type b/k and high degree of polymorphism exhibited at each MHC locusWithin an inbred strain of mice, all animals are homozy￾gous at each MHC locus. When mice from two different in￾bred strains, with haplotypes b and k, for example, are mated, all the F1 progeny inherit one haplotype from each parent (see Figure 7-2a). These F1 offspring have the MHC type b/k and can accept grafts from either parent. Neither of the parental strains, however, can accept grafts from the F1 offspring be￾cause each parent lacks one of the F1 haplotypes. MHC inher￾itance in outbred populations is more complex, because the high degree of polymorphism exhibited at each MHC locus Transplantation Immunology CHAPTER 21 483 VISUALIZING CONCEPTS (a) Autograft acceptance Grafted epidermis Blood vessels Days 3–7: Revascularization (b) First-set rejection Grafted epidermis (c) Second-set rejection Grafted epidermis Days 3–7: Revascularization Days 3–4: Cellular infiltration Mediators Days 7–10: Healing Neutrophils Days 12–14: Resolution Days 10–14: Thrombosis and necrosis Damaged blood vessels Blood clots Necrotic tissue Days 7–10: Cellular infiltration Days 5–6: Thrombosis and necrosis Necrotic tissue Blood clots FIGURE 21-1 Schematic diagrams of the process of graft ac￾ceptance and rejection. (a) Acceptance of an autograft is com￾pleted within 12–14 days. (b) First-set rejection of an allograft begins 7–10 days after grafting, with full rejection occurring by 10–14 days. (c) Second-set rejection of an allograft begins within 3–4 days, with full rejection by 5–6 days. The cellular infiltrate that invades an allograft (b, c) contains lymphocytes, phagocytes, and other inflammatory cells