Etiologic agents: Hepatitis viruses -A. B. C. D. E. The hepatitis viruses(p251, 11-1) HAy HBv HCV ADDy HEy Year of idenification 1973 1965 1989 1977 1980 nn 42. nm 30-60nm 35-nm 32-34nm Agent Icosahedral Enveloped Enveloped Enveloped SsRNA; Unenvelope capsid, SsRNA dsDNA SSRNA replication defective d ssRNA Classification picornavirus hepadnavirus flavivirus unknown caliciviridae #r Transmission fecal-oral close contact fi close contact contact waterborne Incubation period(weeks) 2-6 4-26 2-26 Fuminant 0.1-0.4% rare 4% in coinfection 0.3-3% hepatitis 20% in pregnant women Carrier state None 0.1-1% 0.2-1% 1-10% None Chronic 5-10% >70% 5 coinfection None hepatiti 80% superinfection H Carcinoma No Y NoEtiologic agents: Hepatitis viruses — A．B．C．D．E. The hepatitis viruses (p251, 11-1) HAV HBV HCV HDV HEV Year of idenification 1973 1965 1989 1977 1980 Agent 27-nm 42-nm 30-60nm 35-nm 32-34nm Iscosahedral capsid, ssRNA Enveloped dsDNA Enveloped ssRNA Enveloped ssRNA; replication defective Unenvelope d ssRNA Transmission fecal-oral close contact 血 close contact contact waterborne Classification picornavirus hepadnavirus flavivirus黄 unknown caliciviridae 杯 Incubation period (weeks) 2-6 4-26 2-26 4-7 2-8 Fuminant hepatitis 0.1-0.4% <1% rare 3-4% in coinfection 0.3-3%; 20% in pregnant women Carrier state None 0.1-1% 0.2-1% 1-10% None Chronic hepatitis None 5-10% >70% <5 coinfection None 80% superinfection H. Carcinoma No Yes Yes No No 5