Definition Leukemia is a clonal, malignant disease of hematopoietic tissue that is characterized by O the proliferation of abnormal leukemic cells, principallyin the marrow 2) impaired production of normal blood cells (3) infiltration in tissue and organs Thus, the leukemic cell infiltration in marrow is accompanied nearl invariably by anemia and thrombocytopenia. The absolute neutrophil count may be low or normal, depending on the total white cell count Also, Hepatomegaly, Splenomegaly and lymphopathy because of infiltration in tissue and organsDefinition ⚫ Leukemia is a clonal, malignant disease of hematopoietic tissue that is characterized by: (1) the proliferation of abnormal leukemic cells, principally in the marrow; (2) impaired production of normal blood cells. （3）infiltration in tissue and organs Thus, the leukemic cell infiltration in marrow is accompanied, nearly invariably, by anemia and thrombocytopenia. The absolute neutrophil count may be low or normal, depending on the total white cell count. Also, Hepatomegaly, Splenomegaly and lymphopathy because of infiltration in tissue and organs