2, The opposing pathways of glycolysis and gluconeogenesis have 3 reactions different and 7 reactions in common The reversible reactions between pyruvate and glucose are shared by gluconeogenesis and glycolysis, but the irreversible reactions are different (bypassed? in gluconeogenesis2. The opposing pathways of glycolysis and gluconeogenesis have 3 reactions different and 7 reactions in common • The reversible reactions between pyruvate and glucose are shared by gluconeogenesis and glycolysis, but the irreversible reactions are different (“bypassed” in gluconeogenesis)