1.The significance of the EC50/ED50. 2.For anoptimalchoice of a drug,either potency or Emax is crucial? Chapter4Drug Biotransformation I.TeachingObjectives 1.1 To leam the key procedures of drug biotransformation. 1.2 To leam the roles of biotransformation in drug disposition 1.3 To leam the majororgans where drug biotransformation occurs. 1.4 To understand the enzymes involved in biotransformation. 2.Teaching main and difficult points 2.1 Human Liver P450 Enzymes 2.2 Induction inhibition of P450. 3.Course Contents 3.1.The roles ofbiotransformation. 3.2.Human Liver P450 Enzymes. Induction inhibition of P450. 3.3.Toxicity of Acetaminophen. 4.Teaching Methods By using multimedia teaching method,off-line,on-line method,student-centered method and other diversified teaching methods,we inspire students to"leam with questions"and cultivate students'critical thinking ability 5.Teaching Evaluation 5.1 Discussion1. The significance of the EC50/ED50. 2. For an optimal choice of a drug, either potency or Emax is crucial? Chapter4Drug Biotransformation 1.Teaching Objectives 1.1 To learn the key procedures of drug biotransformation. 1.2 To learn the roles of biotransformation in drug disposition. 1.3 To learn the major organs where drug biotransformation occurs. 1.4 To understand the enzymes involved in biotransformation. 2.Teaching main and difficult points 2.1 Human Liver P450 Enzymes 2.2 Induction & inhibition of P450. 3. Course Contents 3.1. The roles of biotransformation. 3.2. Human Liver P450 Enzymes. Induction & inhibition of P450. 3.3. Toxicity of Acetaminophen. 4.Teaching Methods By using multimedia teaching method, off-line, on-line method, student-centered method and other diversified teaching methods, we inspire students to “learn with questions” and cultivate students’ critical thinking ability. 5.Teaching Evaluation 5.1 Discussion