4.耐药机制 (1)生成β内酰胺酶(β- actamase) H 1 Site of action of penicillinase R--C--NH-CH-CH C 2 Site of action of amidase 2 IBIA CH 3 O=C--N--CH--COOH A Thiazolidine ring 1合 Penicillins B阝 Lactam ring Penicillinase Amidase (青霉素酶 〔酰胶酶)S、Ch CH -CH+ NH2-CH-CH C R--CH-NH-CH-CH CH 3 CH3 O=C-N-CH-COOH O=C N-CH--COOH HH R +6-Aminopenicillanic Acid Penicilloic Acids (6-氨基青霉烷酸) (青霉素裂解酸)(酰胺酶) (青霉素酶) (6-氨基青霉烷酸) (青霉素裂解酸) (1) 生成-内酰胺酶(-lactamase) 4. 耐药机制: