河北医科大学药学院 《彩响人羹历吏进程的100名人排行梅》Fleming列第45位 1964 Nobel Prize in Chemistry 体王国之花 1910-1994 C CLE 提取分离纯化的重要性 的什么emg漫有得到青素？“神青药物”应平10年丹 “抗生素”之父：Selman A.Vaksman The Story of Streptomycin TIME K.A.Folkers deter 天然药物化学教研室史清文教授河北医科大学药学院 天然药物化学教研室史清文教授 6 151 It is now known that the target of the penicillins are the penicillin binding proteins transpeptidases . 《影响人类历史进程的100名人排行榜》Fleming列第45位 152 1964 Nobel Prize in Chemistry 晶体王国之花 Penicillin G Dorothy Crowfoot Hodgkin X-ray 和生物小分子结构分析 X-ray 和Dorothy Hodgkin (1910 - 1994) Penicillium chrysogeum 1945 Nobel Prize in Medicine Google commemorated Hodgkin's 104th birthday，May 12, 2014 Sir Robert Robinson did not like the b-lactam structure because this would be unstable, unlike penicillin. They were taken aback when a young woman... John W. Cornforth said “If penicillin turns out to have the b-lactam structure I shall give up chemistry and grow mushrooms.” He did not keep his threat but later received a Nobel prize for his enzyme work 30 years later. 提取分离纯化的重要性 Alexander Fleming 1881 - 1955 Ernst Chain 1906-1979 为什么Fleming没有得到青霉素？“神奇药物”应该提早10年问世？ Waksman 155 isolated it in 1942-3 and received Nobel Prize in 1952. K. A. Folkers determinde its structure in 1948. 链霉素是第一个氨基糖苷类抗生素，是第一个用于肺结核治疗的 药物，结核相当于现在的癌症，它发现改变了现代医学的进程。 Streptomycin “土壤之人” S. A. Waksman Albert Schatz O O OH O O OH HO HO HO HO OH OHC NH NH2 HN HN H2N NH NHMe “抗生素”之父: Selman A. Waksman 156 Streptomyces griseus O O OH O O OH HO HO HO HO OH OHC NH NH2 HN HN H2N NH NHMe The Story of Streptomycin The first of a class of drugs called aminoglycosides to be discovered. It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system