System Overview Sophisticated feedback, >Neural mechanism. Mechanical forces, etc Autonomic nervous system Local circulation (sympathetic division) Resting vasomotor tone >Myogenic mechanism: Vasomotor control >Metabolic mechanism. Electrical and chemical signalling PO2, pH, etc /SMCs→ ECS >Endothelial mechanism NO, EDHF, PGI2, ET, EDCF, etc Gap junction➢Neural mechanism: Autonomic nervous system (sympathetic division) ➢Myogenic mechanism: ➢Metabolic mechanism: PO2 , pH, etc. ➢Endothelial mechanism: NO, EDHF, PGI2 , ET, EDCF, etc. System Overview Resting vasomotor tone ECs VSMCs Gap junction Electrical and chemical signalling Vasomotor control Sophisticated feedback, Mechanical forces, etc. Local circulation