System Overview Neural, myogenic, metabolic, and endothelial mechanisms control regional blood flow >Neural mechanism. Blood pressure Autonomic nervous system-+ Cardiac output (sympathetic division) Local blood flow >Myogenic mechanism: Autoregulation in the vessels of heart, brain, skeletal muscle, and kidneys >Metabolic mechanism: Local control in the vessels of heart PO2, pH, etc >Endothelial mechanism NO, EDHF, PGI2, ET, EDCF, etc Relaxing or contracting VSMCSNeural, myogenic, metabolic, and endothelial mechanisms control regional blood flow ➢Neural mechanism: Autonomic nervous system (sympathetic division) ➢Myogenic mechanism: ➢Metabolic mechanism: PO2 , pH, etc. ➢Endothelial mechanism: NO, EDHF, PGI2 , ET, EDCF, etc. System Overview Autoregulation in the vessels of heart, brain, skeletal muscle, and kidneys Blood pressure Cardiac output Local blood flow Local control in the vessels of heart, brain, skeletal muscle during exercise Relaxing or contracting VSMCs