How these voltage-gated ion channels work >movement of the voltage sensor generates a gating current S4 transmembrane segment may be voltage sensor >pore formed by a nonhelical region between helix 5 and 6(postulated to form β sheets) >inactivation gate is in the cytoplasm41 How these voltage-gated ion channels work ➢movement of the voltage sensor generates a gating current ➢S4 transmembrane segment may be voltage sensor ➢pore formed by a nonhelical region between helix 5 and 6 (postulated to form b sheets) ➢inactivation gate is in the cytoplasm