Na+ channel conformations Closed Open Inactivated Outside Inside on-conducting Conducting Another Non-conducting conformation(s) conformation conformation (at negative potentials) (shortly after/ more depolarized potentials depolarized potentia42 Na+ Channel Conformations Conducting conformation Non-conducting conformation(s) (at negative potentials) (shortly after more depolarized potentials) Another Non-conducting conformation (a while after more depolarized potentials) IFM IFM IFM Closed Open Inactivated Outside Inside