Basic medical College of fudan University Final Exam of medical Genetics in 2014-2015(1) MBBS A Name Student number: section I ABC Total scores A Multiple choice questions(select the single correct answer)( 20%) 1. Which event is NOT normally associated with development of cancer? A. Infection of a cell with a virus that carries an oncogene B. Activation of genes encod ing telomerase in somatic cells C Inactivation of a tumor-suppressor gene in a cell D. Chromosome rearrangements includ ing insertions and deletions a proto-oncogene in a cel 2. Which of the following clinical features are not characteristic of familial cancer syndromes? A. Earlier mean age of cancer onset, compared to sporadic form of the same tumor type B. More often involve mutation in tumor suppressor genes than oncogenes C Observed tumor types are rarely seen as sporadic cancers D. One or more close relatives are affected by the same rare tumor E. Two or more independent primary tumors in a single individual 3. Why is familial retinoblastoma known to be inherited as an autosomal dominant trait when the responsible gene is recessive? A. This recessive gene needs only one copy to express this phenotype B. People with this mutation are always homozygous for this allele C. If you are born with one allele mutated in every cell, the chance that the other allele will be mutated in one of the retinal cells is extremely high D Retinoblastoma was mischaracterized originally when it was called an autosomal dominant trait E. If you are born with one allele mutated in every cell, the chance that the other allele will be mutated in one of the retinal cells is extremely high 4. Card iovascular diseases are the lead ing cause of deaths globally. Of the following cardiovascular diseases, which one is usually not considered as a congenital heart defect? A. Pulmonary Atresia B. Tetralogy of Fallot C. Loeffler endocarditis D. Ventricular Septal DefectBasic Medical College of Fudan University Final Exam of Medical Genetics in 2014-2015 (1) MBBS □ A Name ： Student Number： section A B C Total scores scores A. Multiple choice questions (select the single correct answer) ( 20%) 1. Which event is NOT normally associated with development of cancer? A. Infection of a cell with a virus that carries an oncogene B. Activation of genes encoding telomerase in somatic cells C. Inactivation of a tumor-suppressor gene in a cell D. Chromosome rearrangements including insertions and deletions E. Inactivation of a proto-oncogene in a cell 2. Which of the following clinical features are NOT characteristic of familial cancer syndromes? A. Earlier mean age of cancer onset, compared to sporadic form of the same tumor type B. More often involve mutation in tumor suppressor genes than oncogenes C. Observed tumor types are rarely seen as sporadic cancers D. One or more close relatives are affected by the same rare tumor E. Two or more independent primary tumors in a single individual 3. Why is familial retinoblastoma known to be inherited as an autosomal dominant trait when the responsible gene is recessive? A. This recessive gene needs only one copy to express this phenotype. B. People with this mutation are always homozygous for this allele. C. If you are born with one allele mutated in every cell, the chance that the other allele will be mutated in one of the retinal cells is extremely high. D. Retinoblastoma was mischaracterized originally when it was called an autosomal dominant trait. E. If you are born with one allele mutated in every cell, the chance that the other allele will be mutated in one of the retinal cells is extremely high. 4. Cardiovascular diseases are the leading cause of deaths globally. Of the following cardiovascular diseases, which one is usually not considered as a congenital heart defect? A. Pulmonary Atresia B. Tetralogy of Fallot C. Loeffler endocarditis D. Ventricular Septal Defect