E. Transposition of the Great Arteries 5. Many factors can increase the risk of giving birth to a baby with Spina Bifida. which one is usually not a risk factor in causing spina bifida? a folate defic B. anti-seizure Ications D. smoking E. feve 6. Birth defects affect 1 in every 33 babies born in the United States each year. Which of the following birth defects is the least common one? A Spina bifida B. Club foot C Anencephaly Down Syndrome E. Cleft lip 7. Thalidomide has anti-angiogenic and anti-inflammatory effects. Which statement concerning thalidomide is incorrect? A. It has anti-cancer effects B. It causes birth defects of limbs C. It was first marketed in Germany by Boehringer Ingelheim D. It was used to alleviate morning sickness of pregnant women E. It binds and inactivates cereblon 8. Approximately how many base pairs are found in the human haploid genome? A.6,200,000(62 million) B.6,2000000(62 billion) C.6,200,000,000,000(62 trillion) D.3,100,0000031 billion) E.3,100,0000003.1 trillion) 9. How many chromosomes comprise the normal human karyotype A 48 autosomal chromosomes plus 2"chromosomes B 46 autosomal chromosomes plus 2sex"chromosomes C 44 autosomal chromosomes plus 2"sex "chromosomes D 42 autosomal chromosomes plus 2"sex "chromosomes E 40 autosomal chromosomes plus 2sex"chromosomes 10. Which of the following disorders is not cause by the listed chromosome abnormality? A. Down syndrome: trisomy 22 C Klinefelter syndrome: 47, XXY D Smith-Magenis syndrome: 17p112 deletion E Cri du chat syndrome: 5p deletionE. Transposition of the Great Arteries 5. Many factors can increase the risk of giving birth to a baby with Spina Bifida. Which one is usually not a risk factor in causing Spina Bifida? A. folate deficiency B. anti-seizure medications C. obesity D. smoking E. fever 6. Birth defects affect 1 in every 33 babies born in the United States each year. Which of the following birth defectsis the least common one? A. Spina Bifida B. Club foot C. Anencephaly D. Down Syndrome E. Cleft lip 7. Thalidomide has anti-angiogenic and anti-inflammatory effects. Which statement concerning thalidomide is incorrect? A. It has anti-cancer effects B. It causes birth defects of limbs C. It was first marketed in Germany by Boehringer Ingelheim D. It was used to alleviate morning sickness of pregnant women E. It binds and inactivates cereblon 8. Approximately how many base pairs are found in the human haploid genome? A. 6,200,000 (6.2 million) B. 6,200,000,000 (6.2 billion) C. 6,200,000,000,000 (6.2 trillion) D. 3,100,000,000 (3.1 billion) E. 3,100,000,000,000 (3.1 trillion) 9. How many chromosomes comprise the normal human karyotype? A. 48 autosomal chromosomes plus 2 “sex” chromosomes B. 46 autosomal chromosomes plus 2 “sex” chromosomes C. 44 autosomal chromosomes plus 2 “sex” chromosomes D. 42 autosomal chromosomes plus 2 “sex” chromosomes E. 40 autosomal chromosomes plus 2 “sex” chromosomes 10. Which of the following disorders is not cause by the listed chromosome abnormality? A. Down syndrome: trisomy 22 B. Turner syndrome: 45, X C. Klinefelter syndrome: 47, XXY D. Smith-Magenis syndrome: 17p11.2 deletion E. Cri du Chat syndrome: 5p deletion