Antigen binding tol Activation of Changes in and cross-linking B lymphocytes phenotype Functional consequences of membrane Ig function of Ig-mediated B cell activation Entry into cell cycle: mitosis Increase in expression of Naive B costimulators(such as B7) lymphocyte B7 Increased expression of costimulators 2. Increase in expression of and cytokin CKRs Cytokine receptors receptor 3. Decrease in their MIgM expression of receptors Low level IgM secretion for chemokines produced in lymphoid folicles B cell response to antigen Significance Entry into cell cycle, mitosis Clonal expansion ncreased expression o Ability to activate B7 costimulators helper T cells Increased expression of Ability to respond to cytokines cytokine receptors produced by helper T cells Migration out of Interaction with lymphoid follicles helper T cells Secretion of low levels Early phase of humoral of igM Immune response ElsevierabBas&LichtmanBasicImmunologyupdated2e-www.studentconsult.coFunctional consequences of Ig-mediated B cell activation: 1. Increase in expression of costimulators (such as B7) 2. Increase in expression of CKRs 3. Decrease in their expression of receptors for chemokines produced in lymphoid folicles