Anticancer immunotherapy by CtLA-4 blockade relies on the Science gut microbiota Marie vetizou, Jonathan M. Pitt, Romain Daillere, Patricia Lepage Nadine Waldschmitt, Caroline Flament, Sylvie Rusakiewicz, NAAAS Bertrand Routy, Maria P Roberti, Connie P. M. Duong, Vichnou Poirier-Colame. Antoine Roux. Sonia Becharef. Silvia Formenti Encouse Golden, Sascha Cording, Gerard Eberl, Andreas Schlitzer Florent Ginhoux. Sridhar Mani. Takahiro Y amazaki. Nicolas Jacquelot, David P Enot, Marion Berard, Jerome Nigou, Paule Opolon, Alexander Eggermont, Paul-Louis Woerther, Elisabeth hachaty, Nathalie Chaput, Caroline Robert, Christina Mateus undo Kroemer, Didier Raoult, Ivo Gomperts Boneca, Franck Carbonnel, Mathias Chamaillard and laurence Zitvogel(November Science350(6264),1079-1084.[doi:10.1126/ science aad l329 originally published online November 5, 2015 Editor's Summary Gut microbes affect immunotherapy The unleashing of antitumor T cell responses has d in a new era of cancer treatment Although these therapies can cause dramatic tumor regre In some patients, many patients lexplicably see no benefit. Mice have been used to investigate what might be happening Perspective by Snyder et al. ) vetizou et al. found that optimal responses to anticytotoxic T lymphocyte ntigen blockade required specific Bacteroides spp. Similarly, Sivan et al. discovered that Bifidobacterium spp. enhanced the efficacy of antiprogrammed cell death ligand I therapy Science, this issue, p. 1079 and p. 1084; see also p. 1031 09月55885 This copy is for your personal, non-commercial use only =88 Article Tools Visit the online version of this article to access the personalization and article tools http://science.sciencemag.org/content/350/6264/1079 Permissions Obtain information about reproducing this article http://www.sciencemag.org/about/permissions.dtl Science(print IssN 0036-8075 online Issn 1095-9203)is published weekly, except the last week in December, by the American Association for the Advancement of Science, 1200 New York Avenue Nw, Washington, DC 20005. Copyright 2016 by the American Association for the Advancement of Science; all rights reserved. The title Science is a registered trademark of AAAsoriginally published online November 5, 2015 Science 350 (6264), 1079-1084. [doi: 10.1126/science.aad1329] 5, 2015) Carbonnel, Mathias Chamaillard and Laurence Zitvogel (November Guido Kroemer, Didier Raoult, Ivo Gomperts Boneca, Franck Chachaty, Nathalie Chaput, Caroline Robert, Christina Mateus, Opolon, Alexander Eggermont, Paul-Louis Woerther, Elisabeth Jacquelot, David P. Enot, Marion Bérard, Jérôme Nigou, Paule Florent Ginhoux, Sridhar Mani, Takahiro Yamazaki, Nicolas Encouse Golden, Sascha Cording, Gerard Eberl, Andreas Schlitzer, Poirier-Colame, Antoine Roux, Sonia Becharef, Silvia Formenti, Bertrand Routy, Maria P. Roberti, Connie P. M. Duong, Vichnou Nadine Waldschmitt, Caroline Flament, Sylvie Rusakiewicz, Marie Vétizou, Jonathan M. Pitt, Romain Daillère, Patricia Lepage, gut microbiota Anticancer immunotherapy by CTLA-4 blockade relies on the Editor's Summary Science, this issue, p. 1079 and p. 1084; see also p. 1031 Bifidobacterium spp. enhanced the efficacy of antiprogrammed cell death ligand 1 therapy. antigen blockade required specific Bacteroides spp. Similarly, Sivan et al. discovered that Perspective by Snyder et al.). Vétizou et al. found that optimal responses to anticytotoxic T lymphocyte Specific members of the gut microbiota influence the efficacy of this type of immunotherapy (see the inexplicably see no benefit. Mice have been used in two studies to investigate what might be happening. Although these therapies can cause dramatic tumor regressions in some patients, many patients The unleashing of antitumor T cell responses has ushered in a new era of cancer treatment. Gut microbes affect immunotherapy This copy is for your personal, non-commercial use only. Article Tools http://science.sciencemag.org/content/350/6264/1079 article tools: Visit the online version of this article to access the personalization and Permissions http://www.sciencemag.org/about/permissions.dtl Obtain information about reproducing this article: Advancement of Science; all rights reserved. The title Science is a registered trademark of AAAS. Avenue NW, Washington, DC 20005. Copyright 2016 by the American Association for the in December, by the American Association for the Advancement of Science, 1200 New York Science (print ISSN 0036-8075; online ISSN 1095-9203) is published weekly, except the last week on June 24, 2016 http://science.sciencemag.org/ Downloaded from