Tr:T Regulatory Cells Review:Roncarolo Curr Opinion Immunol 2000 CD4+CD45RB TGFβ，IL10 Colitis by CD45RBhi Th3 TGFB,+/- EAE,glomeruloneph,MG, IL10,IL4 clone DM TRI IL10,normal IBD by CD45RBi TGFB,no IL4 Respond IL-15 CD4+CD25+ CTLA4 Thymectomy autoimmune (?=TR1) Constituitive CTLA4 Other CD4+ IL2,IFNy MBP EAE model CD8+ Oral tolerance intestine CD4-CD8-TCRaβ Fas Skin Allograft Gamma/Delta Gut,Nasal Insulin NKT IL4,IL10,IFNy, CD1 Activated TGFBTr: T Regulatory Cells Review: Roncarolo Curr Opinion Immunol 2000 CD4+CD45RBlo TGF, IL10 Colitis by CD45RBhi Th3 TGF,+/- IL10,IL4 EAE, glomeruloneph, MG, clone DM TR1 IL10, normal TGF,no IL4 IBD by CD45RBhi , Respond IL-15 CD4+CD25+ (? =TR1) CTLA4 Thymectomy autoimmune Constituitive CTLA4 Other CD4+ IL2, IFN MBP EAE model CD8+ Oral tolerance intestine CD4-CD8-TCR Fas Skin Allograft Gamma/Delta Gut, Nasal Insulin NKT IL4,IL10,IFN, TGF CD1 Activated BDC