Th1 ys.Th2 CD4 T Cells Thl Th2 IL-12 for differentiation IL-4 for differentiation Cytokines: Cytokines: Interferon-y Inerluekin-4 Interleukin-5 Interleukin-2 Interluekin-13 Intracellular Pathogens Extracellular Pathogens ·CD8 Cytotoxicity B Cell activation IgE .Delayed Type Hypersensitivity Immunoglobulin Macrophage Activation Eosinophil responses BDC Th1 vs. Th2 CD4 T Cells Th1 • IL-12 for differentiation • Cytokines: Interferon- Interleukin-2 • Intracellular Pathogens • CD8 Cytotoxicity • Delayed Type Hypersensitivity • Macrophage Activation Th2 • IL-4 for differentiation • Cytokines: Inerluekin-4 Interleukin-5 Interluekin-13 • Extracellular Pathogens • B Cell activation & IgE Immunoglobulin • Eosinophil responses BDC