Human papilloma virus(HPv) (Image removed due to copyright considerations. HPV(human papilloma virus) infects epithelial cells causing warts. It is a sexually- transmitted disease and can form these lesions in the anogenital tracts (known as condyloma accuminata). There are several forms of HPv that vary on their malignancy. Some only produce the warts(as HPV-6 and -7)whereas others, such as HPV-16 and -18 are associated to malignant lesions such as cervical cancer. These malignant forms encode the oncoproteins E6 and E7 both able to bind cell regulatory proteins: p53(E6)and pRB (E7) In the case of E6, this oncoprotein is able to interact with a cellular E3 protein ligase (E6-AP)so it ubiquitinates p53. E6 enhances p53 degradation, preventing the (Image removed due to copyright considerations.) infected cell from undergoing apoptosis so the virus can then ensure its proliferation. Similarly, E7 also prevents programmed cell death by destabilization of That's one of many reasons why it's so important to use sexual protection and to go through regular Pap smear check-ups if you are a woman. Direct contact with the warts can transmit the disease. Men can also develop anal cancer through HPV infectionHuman papilloma virus (HPV) (Image removed due to copyright considerations.) ) infects epithelial cells causing warts. It is a sexually￾transmitted disease and can form these lesions in the anogenital tracts (known as condyloma accuminata). There are several forms of HPV that vary on their malignancy. Some only produce the warts (as HPV-6 and –7) whereas others, such as HPV-16 and –18 are associated to malignant lesions such as cervical cancer. These malignant forms encode the oncoproteins E6 and E7 both able to bind cell regulatory proteins: p53 (E6) and pRB (E7). HPV (human papilloma virus) In the case of E6, this oncoprotein is able to interact with a cellular E3 protein ligase (E6-AP) so it ubiquitinates p53. E6 enhances p53 degradation, preventing the infected cell from undergoing apoptosis so the virus can then ensure its own proliferation. Similarly, E7 also prevents programmed cell death by destabilization of pRB. That’s one of many reasons why it’s so important to use sexual protection and to go through regular Pap smear check-ups if you are a woman. Direct contact with the warts can transmit the disease. Men can also develop anal cancer through HPV infection. (Image removed due to copyright considerations.) (Image removed due to copyright considerations.)