A mutation in the apoptotic pathway downstream of p53 will block the induction of prog by p5. TGF-B ↑p27 ↑p6 ↑GADD45 p21↑ CDK pICyclin-CDK -*Cyclin-CDK Cyclin Rb-E2F b-(P)+E2F Tx genes ( Figure by MIT OCw.)• A mutation in the apoptotic pathway downstream of p53 will block the induction of programmed cell death by p53. (Figure by MIT OCW.)