balance imbalance of Coagulation-anticoagulation Coagulation system Anticoagulation system VEc TFPI, PC, PS, Extrinsic Intrinsic AT-II, Heparin system system Microcirculation fibrinolysis TF XIa other factor Coagulation status ChangeCoagulation system Extrinsic system Intrinsic system Anticoagulation system VEC Microcirculation TFPI, PC, PS, AT-III , Heparin Coagulation status Change TF XIIa other factor fibrinolysis balance & imbalance of Coagulation-anticoagulation