Chapter 9 Coagulation-anticoagulation balance imbalance of haemostatic system Zhao mingyao BMC.ZZU
Zhao Mingyao BMC.ZZU Coagulation-anticoagulation balance & imbalance of haemostatic system Chapter 9
Red blood cell Brokenblood wessel wall Platelet Activated platelet Clot Fibrin
Section 1 Overview of haemostatic system Thrombin Plasmin Fibrin FDP Coagulation and blood flowing
Section 1 Overview of haemostatic system Thrombin Fibrin Plasmin ? FDP . . . . . Coagulation and blood flowing
Fibrinogen Thrombin Fibrin mesh Factor Xf Crosslinked fibrin mesh Other FDPs D-dimer Pasir Clot formation(electron microscope)
Clot formation (electron microscope)
Contact activation X v ATⅢ Protein S prothrombin-- thrombin ATⅢl APC fibrinogen FDP terrin Protein C TM endotheliul liver FDP fibrin U-PA HPAl-I aminogen plasmin (D-dimer a2antpasmun
TF liver endothelium TM
Complex formation of clotting factors MEMBRANE PHOSPHOLIPID- DEPENDENT REACTIONS NBL。oDc。 AGULAT|oN PIt Ⅷ、ⅸ、Ca2++plt aet。rX Ⅹ、V、Ca2+plt o rfn avul
Ⅷ、Ⅸ、Ca2+ + plt Ⅹ、Ⅴ、Ca2+ + plt Complex formation of clotting factors Plt
3 steps of coagulation 1. Prothrombin activator formation 2. Thrombin formation Contact actat 3. Fibrin formation
1.Prothrombin activator formation 2. Thrombin formation 3.Fibrin formation 3 steps of coagulation
Section 2 Imbalance in haemostatic system
Section 2 Imbalance in haemostatic system
balance imbalance of Coagulation-anticoagulation Coagulation system Anticoagulation system VEc TFPI, PC, PS, Extrinsic Intrinsic AT-II, Heparin system system Microcirculation fibrinolysis TF XIa other factor Coagulation status Change
Coagulation system Extrinsic system Intrinsic system Anticoagulation system VEC Microcirculation TFPI, PC, PS, AT-III , Heparin Coagulation status Change TF XIIa other factor fibrinolysis balance & imbalance of Coagulation-anticoagulation
Major types 1. Bleeding disorder inherited acquired 2. Thrombogenesis and thrombotic disorders 3. Blood vessel abnormity: VEC. Factors activation 4. Fibrinolytic factors abnormity
Major types 1.Bleeding disorder: inherited ~ & acquired ~ 2.Thrombogenesis and thrombotic disorders 3.Blood vessel abnormity: VEC, Factors activation 4.Fibrinolytic factors abnormity