MODE OF ACTION GLUCOCORTICOIDS IN PREVENTING INFLAMMATION Intracellular membrane phospholipids Steroid receptor Phospholipase a Arachidonic acid Synthesis lipocortin or annexin 1 prostaglandin Represses inhibits inducible COX2 Release into cytosol or from cell INFLAMMATIONMODE OF ACTION GLUCOCORTICOIDS IN PREVENTING INFLAMMATION Steroid + receptor Represses inducible COX2 Synthesis lipocortin or annexin 1 Intracellular membrane phospholipids Arachidonic acid prostaglandin INFLAMMATION Release into cytosol or from cell Phospholipase A2 inhibits