ANTIINFLAMMATORY EFFECTS OF GLUCOCORTICOIDS April, 1948 1 Gram cortisone isolated by Kendall September 21, 1948 Hench administers 100mg of cortisone by intra muscular injection to patient Mrs. G. suffering chronic Rheumatoid Arthritis September 28, 1948 Mrs G. first time in years walks downtown to go shopping Represented a new approach to therapy with natural hormones by utilising a dose much higher than that naturally produced by the body ie pharmacological rather than physiological doseANTIINFLAMMATORY EFFECTS OF GLUCOCORTICOIDS April, 1948 1 Gram cortisone isolated by Kendall September 21, 1948 Hench administers 100mg of cortisone by intra￾muscular injection to patient Mrs. G. suffering chronic Rheumatoid Arthritis September 28, 1948 Mrs. G. first time in years walks downtown to go shopping. Represented a new approach to therapy with natural hormones by utilising a dose much higher than that naturally produced by the body ie. pharmacological rather than physiological dose