BIOSYNTHESIS OF MINERALOCORTICOIDS HO pregnenolone 18-hydroxy- corticosterone Aldosterone HO c d HOCH2 HOCH2 o Ho HOCH2 HOCH2 CH2 c=o HO CH HO HO progesterone deoxycortico g o cortico sterone sterone C.5-ene-3β- hydroxy OH CH,OH dehydrogenase d. 3-0X0-4. 5-isomerase HO--CH e. 21-hydroxylase Aldosterone f.11β- hydroxylase (hemiacetal form) g. 18-hydroxylaseBIOSYNTHESIS OF MINERALOCORTICOIDS HO HO O HOCH2 O O O O HOCH2 O O HO O HO C HOCH2 CH2 HO O O HO HOCH2 CH O O O HO CH2OH CH O OH progesterone deoxycortico￾sterone cortico￾sterone 18-hydroxy￾corticosterone Aldosterone Aldosterone (hemiacetal form) pregnenolone c,d e f g c. 5-ene-3b-hydroxy dehydrogenase d. 3-oxo-4,5-isomerase e. 21-hydroxylase f. 11b-hydroxylase g. 18-hydroxylase