RESEARCH LETTER /168 168 Y195 Y195 199 199 167 F171C Amlodipine TM6 F171 TM6 M6 UK-59811 TM5 Nimodipine W195 1199 F171 1199 203 F171 M TM6 TM5 M137 TM6 UK-59811 DMPC omplexes with an dipine .n Fo-mated om e module.The racting residu 2016 Macmillan Publishers Limited part of Soringer Nature.All tights reservec RESEARCH Letter Extended Data Figure 2 | Structural comparison of the binding modes of amlodipine, nimodipine, and UK-59811. a, Superposition of CaVAb in complexes with amlodipine (cyan), nimodipine (yellow), and UK-59811 (magenta) at the dihydropyridine binding site viewed from the side of the pore module. The side chains of dihydropyridine-interacting residues are shown in sticks. b, An Fo–Fc simulated annealing omit map contoured at 2.5σ for nimodipine. c, An Fo–Fc simulated annealing omit map contoured at 2.5σ for UK-59811. d, An Fo–Fc simulated annealing omit map contoured at 2.5σ for DMPC. © 2016 Macmillan Publishers Limited, part of Springer Nature. All rights reserved