Goal 1: Design a protein sequence that adopts a given structure. MELKKARSTPAR How to judge success? what resolution is required? must have the correct fold do the side chains all have to have specific, predicted positions? compare stability to native proteins compare structural uniqueness to native proteins must solve the structure to know how well you did!Goal 1: Design a protein sequence that adopts a given structure. MELKKARSTPAR… How to judge success? • what resolution is required? must have the correct fold do the side chains all have to have specific, predicted positions? • compare stability to native proteins • compare structural uniqueness to native proteins • must solve the structure to know how well you did!