A formal statement of the problem: Given a target fold specified by the atomic coordinates of a backbone structure, find a sequence that will fold to that structure There may be many structures that adopt the fold To increase your chances of success try to find one of the most stable Try to minimize the quantity AGold gtolded-Guntold Need a way to a. search through the different possible sequences b. evaluate Agfold Then pick the best sequence as the design What is ignored in this approach?A formal statement of the problem: Given a target fold, specified by the atomic coordinates of a backbone structure, find a sequence that will fold to that structure. There may be many structures that adopt the fold. To increase your chances of success, try to find one of the most stable. Try to minimize the quantity ∆ Gfold = Gfolded - Gunfold Need a way to: a. search through the different possible sequences b. evaluate ∆ Gfold Then pick the best sequence as the design. What is ignored in this approach?