Point mutation Non-Dis junction LOH-Loss of heterozygosity Chromosome Chromosome loss loss duplication wt rb Mutant Rb Recombination Interchromosomal Deletion Recombination Translocation Gene ConversionPoint Mutation Non-Disjunction Chromosome loss & duplication Chromosome loss Recombination Deletion Interchromosomal Recombination Translocation Gene Conversion wt Rb Mutant Rb LOH - Loss of heterozygosity