What chromosomal events convert proto- oncogenes to dominantly acting oncogenes Point mutations(e.g, RAS) Partial deletion mutations (e.g, RTks) Chromosomal translocations that produce novel fusion proteins (e.g, Bcr-abl) Chromosomal translocation to juxtapose a strong promoter upstream and the proto oncogene such that it is inappropriately expressed (e.g, CMyc, Bcl2 gene amplification resulting in overexpression (e.g., N-Myc)What chromosomal events convert proto￾oncogenes to dominantly acting oncogenes • Point mutations (e.g., RAS) • Partial deletion mutations (e.g., RTKs) •Chromosomal translocations that produce novel fusion proteins (e.g., Bcr-Abl) • Chromosomal translocation to juxtapose a strong promoter upstream and the proto￾oncogene such that it is inappropriately expressed (e.g., cMyc, Bcl2) • Gene amplification resulting in overexpression (e.g., N-Myc)