Signaling Pathway via Protein Pl3 Kinase/Akt Signaling Autophagy Signaling Macroautophagy CD19 PI3K-V/Akt MAPK/Erk1/2 Mitophagy Signaling Signaling Mitochondrial b Damage Parkin GPCR AAMP:>AMPK ATP p53/Genotoxic ub-targets *06886 PARL Amino ATMATR DNA-PK GBL mTOR Raptor BNIP3 Signaling PRAS40 BNIP3U/NIX PTEN mTORC2 PIP PTEN PP2A PHLPP12 CTMP O L NEDD1-4 Atg13 FIP200 Oxidative TBK1 ULK1 Suess 47pho p150 p7050g Lamin A PI3K SQSTM1/p62 Tpl2 Beclln-1 Membrane NBR1+LC3-11 PDCD4 TSC2 .(KKo Bcl-2 (Atg14 Nucleation Ambra1 +mTORC1 TSC1 Ambrat Apoptosis Rubicon ATG13 GABAAR Akt Sequestration Atnxin-1 08 P件KFB2 SK-3 SQSTM1/p62 Bim PIP5K A1g16L1 A1g12Atgs 吃 Bcl-2 0号+Nei+Lc3 Cytoplasmic 5p2 5CF Contents ALFY Girdin G5 A1g16L1 Atg3 -PE Fusion Atg5 Atg10 mTORC1 mTORC2 Atg7 Autophagolysosome CDK2 Cyclin Atg7 LC3- Lysosome Atg12 Atg4 LC3Signaling Pathway via Protein