Cytokine Actions Pleiotropy Act on more than one cell type (INFa/B) Redundancy More than one cytokine can do the same thing (IFNo/βand IFNy) 口 Synergy Two or more cytokines cooperate to produce an effect that is different or greater than the combined effect of the two cytokines when functioning separately (IL-12 and IL-8) Antagonism Two or more cytokines work against each other (IL-4 and IL-12) Cytokine Actions ◼ Pleiotropy ◼ Act on more than one cell type (INFa/b) ◼ Redundancy ◼ More than one cytokine can do the same thing (IFNa/b and IFNg) ◼ Synergy ◼ Two or more cytokines cooperate to produce an effect that is different or greater than the combined effect of the two cytokines when functioning separately (IL-12 and IL-8) ◼ Antagonism ◼ Two or more cytokines work against each other (IL-4 and IL-12)