Cytokines can act in three different manners Autocrine Cytokine binds to receptor on cell that secreted it Paracrine Cytokine binds to receptors on near by cells Endocrine Cytokine binds cells in distant parts of the bodyCytokines can act in three different manners ◼ Autocrine ◼ Cytokine binds to receptor on cell that secreted it ◼ Paracrine ◼ Cytokine binds to receptors on near by cells ◼ Endocrine ◼ Cytokine binds cells in distant parts of the body