12.1 Penicillin biosynthesis Glucose NH-L-o-aminoadipic acid (L-a-AAA)+ Glucose NH3+S02--L-cys L-a-AAA-L-cys Glucose+NH3→L-Val L-a-AAA-L-cys-D-val CH3 L-a-AAA CH3 COOH isopenicillin N RCOH Side chein precursor R-CO CH3 COOH penicillin penicillin acylase CH3 H2 CH3 COOH 6APA 兰 Summary of biosynthesis of penicillin from ammoni,sulphate and side chain separate process with immobilised penicillin acylase.12.1 Penicillin biosynthesis