b.Lecture 1 Class XII i.The classification of the cholinesterases a.Acetylcholinesterase:ACH b.Pseudocholinesterase:succinylcholine ii.The classification of cholinesterase inhibitors a.Reversible cholinesterase inhibitors(physostigmine. neostigmine) b.Irreversible cholinesterase inhibitors(organophosphate) iii.Organ system effect of cholinesterase inhibitors a.Central nervous system b.Eye,respiratory tract,gastrointestinal tract c.Cardiovascular system d.Neuromuscular junction- iv.Clinical uses of the cholinomimetics a.The Eye 6 Gastrointestinal and urinary tracts c.Neuromuscular Junction d.Heart: e.Antimuscarinic Drug Intoxication v.Toxicity a..Direct-Acting Muscarinic Stimulants: b.Direct-Acting Nicotinic Stimulants: c.Cholinesterase Inhibitors vi Specific cholinomimetic drugs a.M-cholinoceptor Agonists:Pilocarpine b.Cholinesterase Inhibitors:Neostigmine (Prostigmine) c.Cholinesterase Inhibitors:Organophosphates Cholinoceptor-Blocking Drugs ours required Total Classes required= Days of Study Thu Period of Study Week 1&2-First semester Lecture1 Class XIIⅢ i.The classification of cholinoceptor-blocking Drugs a.M receptors blocking Drugs b.N receptors blocking Drugs i Chemistry and Pharmacokinetics of the M receptors blocking drugs b. Lecture 1 Class XII i. The classification of the cholinesterases a.Acetylcholinesterase: ACH b.Pseudocholinesterase: succinylcholine ii. The classification of cholinesterase inhibitors a. Reversible cholinesterase inhibitors(physostigmine, neostigmine) b. Irreversible cholinesterase inhibitors(organophosphate) iii. Organ system effect of cholinesterase inhibitors a. Central nervous system b. Eye, respiratory tract, gastrointestinal tract c. Cardiovascular system d. Neuromuscular junction￾iv. Clinical uses of the cholinomimetics a. The Eye b. Gastrointestinal and urinary tracts c. Neuromuscular Junction d. Heart: e. Antimuscarinic Drug Intoxication v.Toxicity a..Direct-Acting Muscarinic Stimulants: b. Direct-Acting Nicotinic Stimulants: c. Cholinesterase Inhibitors vi Specific cholinomimetic drugs a. M-cholinoceptor Agonists : Pilocarpine b. Cholinesterase Inhibitors: Neostigmine (Prostigmine) c. Cholinesterase Inhibitors: Organophosphates Cholinoceptor-Blocking Drugs Total hours required = 2 Total Classes required = 1 Days of Study = Thu Period of Study = Week 1&2 –First semester Lecture 1 Class XIII i. The classification of cholinoceptor -blocking Drugs a. M receptors blocking Drugs b. N receptors blocking Drugs ii. Chemistry and Pharmacokinetics of the M receptors blocking drugs