Section I Basic Principles Introduction Total hours required- 2 Total Classes required Days of Study Mor Peri l of Study Week 1&2-First semester Lecture 1 Class I i.How to define pharmacology ii.The Nature of Drugs a.The Physical Nature of Drugs b.Drug Size c.Drug Reactivity and Drug-Receptor Bonds d.Drug Shape e.Rational Drug Design iii.Drug-Body Interaction iv. Ph armacody amic Principle a.Types of Drug-Receptor Interactions b.Agonists That Inhibit Their Binding Molecules and Partial Agonists c.Duration of Drug Action d.Receptors and Inert Binding Sites v.Pharmacokinetic Principles a.Permeation 1.Aqueous diffusion ii.Lipid diffusion ii.Special carriers iv.Endocytosis and Exocytosis b.Fick's Law of Diffusion c.Ionization of Weak Acids and Weak Bases;the Henderson-Hasselbalch Equation Drug Receptors Pharmacodynamics Total hours required= 6 Total Classes required Days of Study Tue,Wed Period of Study Week 3&4-First semester a.Lecture 1 Class IⅡ i.What is the receptor? ii.Macromolecule nature of drug recaptor
Section I Basic Principles Introduction Total hours required = 2 Total Classes required = 1 Days of Study = Mon Period of Study = Week 1&2 –First semester Lecture 1 Class I i. How to define pharmacology ii. The Nature of Drugs a. The Physical Nature of Drugs b. Drug Size c. Drug Reactivity and Drug-Receptor Bonds d. Drug Shape e. Rational Drug Design iii. Drug-Body Interaction iv. Pharmacodynamic Principles a. Types of Drug-Receptor Interactions b. Agonists That Inhibit Their Binding Molecules and Partial Agonists c. Duration of Drug Action d. Receptors and Inert Binding Sites v. Pharmacokinetic Principles a. Permeation i. Aqueous diffusion ii. Lipid diffusion iii. Special carriers iv. Endocytosis and Exocytosis b. Fick’s Law of Diffusion c. Ionization of Weak Acids and Weak Bases; the Henderson-Hasselbalch Equation Drug Receptors & Pharmacodynamics Total hours required = 6 Total Classes required = 3 Days of Study = Tue, Wed Period of Study = Week 3&4 –First semester a. Lecture 1 Class II i. What is the receptor? ii. Macromolecule nature of drug recaptor
iii.Relation between drug concentration response a.Concentration-Effect Curves Receptor Binding of Agonists b.Receptor-Effector Coupling&Spare Receptors c.Competitive Irreversible Antagonists d.Partial Agonists e.Other Mechanisms of Drug Antagonism b.Lecture 2 Class III i.Signaling mechanismsdrug action ntracellular receptors for lipid-soluble agents b. Ligand-regulated transmembrane enzymes including recaptor tyrosine kinases c.Cytokine recaptors d.Ligand-gated channels e.Receptor regulateon c.Lecture 3 Class IV i.Relation between drug dose clinical response a.Dose Response in Patients b.Graded Do Re sponse Relation c.Shape of Dose-Response Curves d.Quantal Dose-Effect Curves ii.Variation in Drug Responsiveness a. Alteration in Concentration of Drug That Reaches the Receptor b.Variation in Concentration of an Endogenous Receptor ligand c.Alteration in Number or Function of Receptors d.Changes in Components of Response Distal to Receptor iii.Clinical Selectivity:Beneficial Versus Toxic Effects of Drugs a.Beneficial and Toxic Effects Mediated by the Same Receptor-Effector Mechanism b.Beneficial and Toxic Effects Mediated by Identical Receptors but in Different Tissues or by Different Effector Pathways c Beneficial and Toxic Effects Mediated by Different Types of Receptors Pharmacokinetics Pharmacodynamics:
iii. Relation between drug concentration & response a. Concentration-Effect Curves & Receptor Binding of Agonists b. Receptor-Effector Coupling & Spare Receptors c. Competitive & Irreversible Antagonists d. Partial Agonists e. Other Mechanisms of Drug Antagonism b. Lecture 2 Class III i. Signaling mechanisms & drug action a. Intracellular receptors for lipid-soluble agents b. Ligand-regulated transmembrane enzymes including recaptor tyrosine kinases c. Cytokine recaptors d. Ligand-gated channels e. Receptor regulateon c. Lecture 3 Class IV i. Relation between drug dose & clinical response a. Dose & Response in Patients b. Graded Dose-Response Relation c. Shape of Dose-Response Curves d. Quantal Dose-Effect Curves ii. Variation in Drug Responsiveness a. Alteration in Concentration of Drug That Reaches the Receptor b. Variation in Concentration of an Endogenous Receptor ligand c. Alteration in Number or Function of Receptors d. Changes in Components of Response Distal to Receptor iii. Clinical Selectivity: Beneficial Versus Toxic Effects of Drugs a. Beneficial and Toxic Effects Mediated by the Same Receptor-Effector Mechanism b. Beneficial and Toxic Effects Mediated by Identical Receptors but in Different Tissues or by Different Effector Pathways c. Beneficial and Toxic Effects Mediated by Different Types of Receptors Pharmacokinetics & Pharmacodynamics:
Rational Dosing the Time Course of Drug Action Total hours required 6 Total Classes required= Days of Study Thu Period ofStudy Week 1&2-First semester a.Lecture 1 Class V i.PHARMACOKINETICS a.Volume of Distribution b.Clearance i.Capacity-Limited Elimination ii.Flow-Dependent Elimination c.Half-Life d.Drug Accumulation b.Lecture 2 Clas s V i.PHARMACOKINETICS e.Bioavailability i.Extent of Absorption ii.First-Pass Elimination iii.Rate of Absorption f.Extraction Ratio the First-Pass Effect g.Alternative Route of Administration the First-Pass Effect ii.THE TIME COURSE OF DRUG EFFECT a.Immediate Effects b.Delayed Effects c.Cumulative Effects iii.THE TARGET CONCENTRATION APPROACH TO N G A RATIONAL DOSAGE REGIMEN a.Maintenance Dose b.Loading Dose c.Lecture3 Class VⅢ i..THERAPEUTIC DRUG MONITORING:RELATING PHARMACOKINETICS OPHARMACODYNAMICS a.Pharmacokinetic Variables i.Absorption
Rational Dosing & the Time Course of Drug Action Total hours required = 6 Total Classes required = 3 Days of Study = Thu Period of Study = Week 1&2 –First semester a. Lecture 1 Class V i. PHARMACOKINETICS a. Volume of Distribution b. Clearance i. Capacity-Limited Elimination ii. Flow-Dependent Elimination c. Half-Life d. Drug Accumulation b. Lecture 2 Class VI i. PHARMACOKINETICS e. Bioavailability i. Extent of Absorption ii. First-Pass Elimination iii. Rate of Absorption f. Extraction Ratio & the First-Pass Effect g. Alternative Route of Administration & the First-Pass Effect ii. THE TIME COURSE OF DRUG EFFECT a. Immediate Effects b. Delayed Effects c. Cumulative Effects iii. THE TARGET CONCENTRATION APPROACH TO D E S I G N I N G A RATIONAL DOSAGE REGIMEN a. Maintenance Dose b. Loading Dose c. Lecture 3 Class VII i.. THERAPEUTIC DRUG MONITORING: RELATING PHARMACOKINETICS & OPHARMACODYNAMICS a. Pharmacokinetic Variables i. Absorption
ii.Clearance iii.Volume of Distribution iy Half-Life b.Pharmacodynamic Variables i.Maximum effect ii.Sensitivity ii.INTERPRETATION OF DRUG CONCENTRATION MEASUREMENTS a.Clearance i.Albumin Concentration 甚&md c n me ein Concentration b.Timing of Samples for Concentration Measurement c.Initial Predictions of Volume of Distribution& Clearance i.Volume of Distribution ii.Clearance d.Revising Individual Estimates of Volume of Distribution Clearance Drug Biotransformation Total hours required= 4 Total Classes required= Days of Study Fri Mon Period of Study Week 1&2-First semester a.Lecture 1 Class VIII i.WHY IS DRUG BIOTRANSFORMATION NECESSARY? ii.THE ROLE OF BIOTRANSFORMATIONIN DRUG DISPOSITION iii.WHERE DO DRUG BIOTRANSFORMATIONS OCCUR? iv.MICROSOMAL MIXED FUNCTION OXIDASE SYST E M & PH ASE REACTIONS a.Enzyme Induction b.Enzyme Inhibition v.PHASEII REACTIONS b.Lecture 2 Class IX
ii. Clearance iii. Volume of Distribution iv. Half-Life b. Pharmacodynamic Variables i. Maximum effect ii. Sensitivity ii. INTERPRETATION OF DRUG CONCENTRATION MEASUREMENTS a. Clearance i. Albumin Concentration ii. α1-Acid Glycoprotein Concentration iii. Capacity-Limited Protein Binding b. Timing of Samples for Concentration Measurement c. Initial Predictions of Volume of Distribution & Clearance i. Volume of Distribution ii. Clearance d. Revising Individual Estimates of Volume of Distribution & Clearance Drug Biotransformation Total hours required = 4 Total Classes required = 2 Days of Study = Fri, Mon Period of Study = Week 1&2 –First semester a. Lecture 1 Class VIII i. WHY IS DRUG BIOTRANSFORMATION NECESSARY? ii. THE ROLE OF BIOTRANSFORMATION IN DRUG DISPOSITION iii. WHERE DO DRUG BIOTRANSFORMATIONS OCCUR? iv. MICROSOMAL MIXED FUNCTION OXIDASE S Y S T E M & P H A S E I REACTIONS a. Enzyme Induction b. Enzyme Inhibition v. PHASE II REACTIONS b. Lecture 2 Class IX
i.METABOLISMOF DRUGS TO TOXIC PRODUCTS ii.CLINICAL RELEVANCE OFDRUG METABOLISM a. Individual Differences b.Genetic Factors c.Diet Environmental Factors d Age Sex e.Drug-Drug Interactions During Metabolism f.Interactions Between Drugs Endogenous Compounds Section I Autonomic Drugs Introduction To Autonomic Pharmacology Total hours required 2 Total Classes required= Davs of Study Mon Period of Study Week 1&2-First semester Lecture 1 Class X Introduction to nervous system ii Anatomy of the autonomic nervous system a.Autonomic nervous system b.Somatic System iii. The anatomic classification of the autonomic system a.Parasympathetic Sympathetic iv.The classification of autonomic system based on the primary transmitter a.Cholinergic fibers b.Noradrenergic fibers(also c.non-adrenergic and non-cholinergic nerve v.The constitution of synapse a.Presynaptic membrane b.Svnaptic cleft c.Postsynaptic membrane vi.Neurotrasmitter chemistry system a.Cholinergic transmission b.Adrenergic transmission: vii.Autonomic receptors a.The classification of autonomic receptors(cholinoceptors. adrenoceptors) b.Locations of autonomic receptors: viii.Functional organization of autonomic activity
i. METABOLISM OF DRUGS TO TOXIC PRODUCTS ii. CLINICAL RELEVANCE OFDRUG METABOLISM a. Individual Differences b. Genetic Factors c. Diet & Environmental Factors d. Age & Sex e. Drug-Drug Interactions During Metabolism f. Interactions Between Drugs & Endogenous Compounds Section II Autonomic Drugs Introduction To Autonomic Pharmacology Total hours required = 2 Total Classes required = 1 Days of Study = Mon Period of Study = Week 1&2 –First semester Lecture 1 Class X i. Introduction to nervous system ii. Anatomy of the autonomic nervous system a. Autonomic nervous system b. Somatic System iii. The anatomic classification of the autonomic System a. Parasympathetic b. Sympathetic iv. The classification of autonomic system based on the primary transmitter a.Cholinergic fibers b.Noradrenergic fibers(also c.non-adrenergic and non-cholinergic nerve v. The constitution of synapse a.Presynaptic membrane b.Synaptic cleft c.Postsynaptic membrane vi. Neurotrasmitter chemistry of the autonomic system a.Cholinergic transmission b.Adrenergic transmission: vii. Autonomic receptors a.The classification of autonomic receptors(cholinoceptors, adrenoceptors) b.Locations of autonomic receptors: viii. Functional organization of autonomic activity
a.In blood vessels b.in the heart c.in the lungs (bronchial smooth muscle) d.In the eye e.Salivary glands f.presynaptic regulation 长Mo2rscenosaendne a.Direct effect on receptors b.Influence the Biosynthesis,Metabolism,Transfer and St orage of the ne urotransmitter x.Classification of autonomic nervous system drugs a.Cholinergic nerve agonists b.Cholinergic nerve antagonists c.Adrenergic nerve agonists d adrenergic nerve antagonists xi.Function of auton omicnervous system a.Functions of the sympathetic system: b.Functions of the parasympathetic system Cholinoceptor-Activating and Cholinesterase-Inhibiting Drugs Total hours required Total Classes required Days of Study Tue.Wed Period of Study Week 3&4-First semester a.Lecture 1 Class XI i.Mode of action of cholinomimetic drugs ii.The classification of cholinoceptor agonist a.Muscarinic receptors stimulants:pilocarpine b.N icotinic receptors stimulants:nicotine c.Muscarinic and nicotinic receptors stimulants iii.Organ system effect of muscarinic receptors stimulants a Eve b.Cardiovascular system- .Smooth muscle:Constriction of smooth muscle d.Glands iv.Organ system effect of nicotinic receptors stimulants a.Central nervous system- b.Peripheral nervous system- c.Neuromuscular junction-
a. In blood vessels b. in the heart c. in the lungs (bronchial smooth muscle) d. In the eye e. Salivary glands: f.presynaptic regulation g.postsynaptic regulation ix. Mode of action of autonomic nervous system drugs a. Direct effect on receptors b.Influence the Biosynthesis, Metabolism, Transfer and Storage of the Neurotransmitter. x. Classification of autonomic nervous system drugs a. Cholinergic nerve agonists b. Cholinergic nerve antagonists c. Adrenergic nerve agonists d. Adrenergic nerve antagonists xi. Function of autonomicnervous system a.Functions of the sympathetic system: b.Functions of the parasympathetic system Cholinoceptor-Activating and Cholinesterase-Inhibiting Drugs Total hours required = 4 Total Classes required = 2 Days of Study = Tue, Wed Period of Study = Week 3&4 –First semester a. Lecture 1 Class XI i. Mode of action of cholinomimetic drugs ii. The classification of cholinoceptor agonist a.Muscarinic receptors stimulants: pilocarpine b.N icotinic receptors stimulants: nicotine c.Muscarinic and nicotinic receptors stimulants iii. Organ system effect of muscarinic receptors stimulants a. Eye b. Cardiovascular systemc..Smooth muscle: Constriction of smooth muscle d. Glands iv.Organ system effect of nicotinic receptors stimulants a.Central nervous systemb.Peripheral nervous systemc.Neuromuscular junction-
b.Lecture 1 Class XII i.The classification of the cholinesterases a.Acetylcholinesterase:ACH b.Pseudocholinesterase:succinylcholine ii.The classification of cholinesterase inhibitors a.Reversible cholinesterase inhibitors(physostigmine. neostigmine) b.Irreversible cholinesterase inhibitors(organophosphate) iii.Organ system effect of cholinesterase inhibitors a.Central nervous system b.Eye,respiratory tract,gastrointestinal tract c.Cardiovascular system d.Neuromuscular junction- iv.Clinical uses of the cholinomimetics a.The Eye 6 Gastrointestinal and urinary tracts c.Neuromuscular Junction d.Heart: e.Antimuscarinic Drug Intoxication v.Toxicity a..Direct-Acting Muscarinic Stimulants: b.Direct-Acting Nicotinic Stimulants: c.Cholinesterase Inhibitors vi Specific cholinomimetic drugs a.M-cholinoceptor Agonists:Pilocarpine b.Cholinesterase Inhibitors:Neostigmine (Prostigmine) c.Cholinesterase Inhibitors:Organophosphates Cholinoceptor-Blocking Drugs ours required Total Classes required= Days of Study Thu Period of Study Week 1&2-First semester Lecture1 Class XIIⅢ i.The classification of cholinoceptor-blocking Drugs a.M receptors blocking Drugs b.N receptors blocking Drugs i Chemistry and Pharmacokinetics of the M receptors blocking drugs
b. Lecture 1 Class XII i. The classification of the cholinesterases a.Acetylcholinesterase: ACH b.Pseudocholinesterase: succinylcholine ii. The classification of cholinesterase inhibitors a. Reversible cholinesterase inhibitors(physostigmine, neostigmine) b. Irreversible cholinesterase inhibitors(organophosphate) iii. Organ system effect of cholinesterase inhibitors a. Central nervous system b. Eye, respiratory tract, gastrointestinal tract c. Cardiovascular system d. Neuromuscular junctioniv. Clinical uses of the cholinomimetics a. The Eye b. Gastrointestinal and urinary tracts c. Neuromuscular Junction d. Heart: e. Antimuscarinic Drug Intoxication v.Toxicity a..Direct-Acting Muscarinic Stimulants: b. Direct-Acting Nicotinic Stimulants: c. Cholinesterase Inhibitors vi Specific cholinomimetic drugs a. M-cholinoceptor Agonists : Pilocarpine b. Cholinesterase Inhibitors: Neostigmine (Prostigmine) c. Cholinesterase Inhibitors: Organophosphates Cholinoceptor-Blocking Drugs Total hours required = 2 Total Classes required = 1 Days of Study = Thu Period of Study = Week 1&2 –First semester Lecture 1 Class XIII i. The classification of cholinoceptor -blocking Drugs a. M receptors blocking Drugs b. N receptors blocking Drugs ii. Chemistry and Pharmacokinetics of the M receptors blocking drugs
a.Source and chemistry: b.Absorption c Distribution and Excretion iii.Organ System Effects of the M receptors blocking drugs a.Eve- b.Cardiovascular system- c..Smooth muscle:Constriction of smooth muscle d Glands- e central neryous system iv.Clinical uses ofthe M receptors blocking drugs a.Central Nervous System Disorders(Parkinson's disease.Motion sickness) b.Ophthalmologic Disorders c.Relaxation of smooth muscle spasm d.Cardiovascular Disorders e Cholinergic Poisoning v.Adverse Effects of the M receptors blocking drugs vi.Contraindications of the M receptors blocking drugs vii.Organ System Effects of the Ni receptors blocking drugs a.Central nervous system b.Eye c.Cardiovascular system d.Gastrointestinal tract e.Other systems f Response to autonomic drugs- viii.Clinical uses of the Ni receptors blocking drugs ix.Adverse Effects of the Ni receptors blocking drugs x.Organ System Effects of the N2 receptors blocking drugs xi.Clinical uses of the N2 receptors blocking drugs xii.Adverse Effects of the N2 receptors blocking drugs Adrenoceptor-Activating Other sympathomimetic drugs Total hours required Total Classes required 2 Days of Study- Fri.Mon Period of Study Week 1&2-First semester a.Lecture 1 Class XIV i.The mode &spectrum of action of sympathomimetic drugs. a.Direct-acting agonists
a. Source and chemistry: b. Absorption c. Distribution: d. Metabolism and Excretion: iii. Organ System Effects of the M receptors blocking drugs a. Eyeb. Cardiovascular systemc..Smooth muscle: Constriction of smooth muscle d. Glandse.Central nervous system iv.Clinical uses of the M receptors blocking drugs a. Central Nervous System Disorders(Parkinson’s disease,Motion sickness) b. Ophthalmologic Disorders c. Relaxation of smooth muscle spasm d. Cardiovascular Disorders e. Cholinergic Poisoning v. Adverse Effects of the M receptors blocking drugs vi. Contraindications of the M receptors blocking drugs vii. Organ System Effects of the N1 receptors blocking drugs a. Central nervous system b. Eye c. Cardiovascular system d. Gastrointestinal tract e. Other systems f.Response to autonomic drugsviii. Clinical uses of the N1 receptors blocking drugs ix. Adverse Effects of the N1 receptors blocking drugs x. Organ System Effects of the N2 receptors blocking drugs xi. Clinical uses of the N2 receptors blocking drugs xii. Adverse Effects of the N2 receptors blocking drugs Adrenoceptor-Activating & Other sympathomimetic drugs Total hours required = 4 Total Classes required = 2 Days of Study = Fri, Mon Period of Study = Week 1&2 –First semester a. Lecture 1 Class XIV i. The mode &spectrum of action of sympathomimetic drugs. a. Direct-acting agonists
b.Indirect-acting agonist c.Mixed-action agonist ii.The identification of adrenoceptors iii.Chemistry pharmacokinetics of sympathomimetic drugs iv.The classification of adrenergic agonists v.Characte tics of adrenergic agonists a.Catecholamines b.Non-catecholamines vi.Organ system effects of sympathomimetic a.Cardiovascular system b.Eye c.Respiratory Tract d.Gastrointestinal Tract e.Genitourinary Tract f.Exocrine Glands Metabolic Effects sisouAooynaI puy uonsund auopuauo1333 i.Effect On The Central Nervous System vii.Clinical uses of sympathomimetic a.Cardiovascular Applications b.Respiratory Applications:Bronchial asthma c.Anaphylaxis d.Ophthalmic Applications e.Genitourinary Applications f.Central Nervous System Applications: g.Additional Therapeutic Uses ity of sympathomimetic drugs b.Lecture 2 Class XV i.Specific sympathomimetic drugs a.Mixed a and B agonists:Epinephrine b.o receptor agonists Norepinephrine .BReceptor Agonists Isoprenaline d.Dopamine Receptor Agonists:Dopamine Adrenoceptor Antagonist Drugs Total hours required= Total Classes required Davs of Study Tue Test= Wednesday Period of Study Week 1&2-First semester
b. Indirect-acting agonist c. Mixed–action agonist ii. The identification of adrenoceptors iii. Chemistry & pharmacokinetics of sympathomimetic drugs iv. The classification of adrenergic agonists v. Characteristics of adrenergic agonists a. Catecholamines b. Non-catecholamines vi. Organ system effects of sympathomimetic a. Cardiovascular system b. Eye c. Respiratory Tract d. Gastrointestinal Tract e. Genitourinary Tract f. Exocrine Glands g. Metabolic Effects h. Effect On Endocrine Function And Leukocytosis i. Effect On The Central Nervous System vii.Clinical uses of sympathomimetic a. Cardiovascular Applications b. Respiratory Applications: Bronchial asthma c. Anaphylaxis: d. Ophthalmic Applications e. Genitourinary Applications f. Central Nervous System Applications: g. Additional Therapeutic Uses: viii. Toxicity of sympathomimetic drugs b. Lecture 2 Class XV i.Specific sympathomimetic drugs a. Mixed and agonists : Epinephrine b. receptor agonists Norepinephrine c. Receptor Agonists Isoprenaline d. Dopamine Receptor Agonists : Dopamine Adrenoceptor Antagonist Drugs Total hours required = 2 Total Classes required = 1 Days of Study = Tue Test= Wednesday Period of Study = Week 1&2 –First semester
Lecture 1 Class XVI 1.The classification of the adrenoceptor antagonist drugs ii.Pharmacologic effects of the a recepto antagonist drugs a.cardiovascular effects b.other effects iii.Clinical pharmacology of the a antagonist drugs iv.Specific agents:Phentolamine, Phenoxybenzamine,Prazosin Yohimbine v.Pharmacokinetic properties of the B antagonist drugs a.Abs orpti b.Bioavailability c.Distribution and clearance vi.Pharmacodynamics of the B R Antagonist Drugs a.Effects on the cardiovasular system b.Effects on the Respiratory Tract: c.Effects onthe Eye d.Metabolic and Endocrine Effects e.Intrinsic sympathomimetic activity (partial agonists) f effects not related to beta blockade vii.Clinical pha acolo r of the B ant aonist drugs viii.Clinical toxicity of the B antagonist drugs Sedative-Hypnotic Drugs Total hours required 2 Total Classes required Days of Study Tue Test= Wednesday Period ofStudy Week 1&2-First semester Lecture 1 Class XVI BASIC PHARMACOLOGY OF SEDATIVE- HYPNOTICS ii.CHEMICAL CLASSIFICATION iii.THE BENZODIAZEPINES BARBITURATES a.Pharmacokinetics i.Absorption ii.Distribution iii.Biotransformation iv.Excretion v.Factors Affecting Biodisposition
Lecture 1 Class XVI i. The classification of the adrenoceptor antagonist drugs ii. Pharmacologic effects of the recepto antagonist drugs a. cardiovascular effects b. other effects iii.Clinical pharmacology of the antagonist drugs iv. Specific agents: Phentolamine, Phenoxybenzamine,Prazosin ,Yohimbine v. Pharmacokinetic properties of the ß antagonist drugs a. Absorption b. Bioavailability c. Distribution and Clearance vi. Pharmacodynamics of the ß R Antagonist Drugs a. Effects on the cardiovasular system b. Effects on the Respiratory Tract: c. Effects on the Eye d. Metabolic and Endocrine Effects: e. Intrinsic sympathomimetic activity (partial agonists) f. Effects not related to Beta blockade vii. Clinical pharmacology of the ß antagaonist drugs viii. Clinical toxicity of the ß antagonist drugs Sedative-Hypnotic Drugs Total hours required = 2 Total Classes required = 1 Days of Study = Tue Test= Wednesday Period of Study = Week 1&2 –First semester Lecture 1 Class XVII i. BASIC PHARMACOLOGY OF SEDATIVEHYPNOTICS ii. CHEMICAL CLASSIFICATION iii. THE BENZODIAZEPINES & BARBITURATES a. Pharmacokinetics i. Absorption ii. Distribution iii. Biotransformation iv. Excretion v. Factors Affecting Biodisposition