R—X+Nu RNu +X Nucleophilic substitution RBr+ Naoh R一OH+NaBr CH3 Br OH ChoH + Br V∝[CH3Br[OH]二级反应 (CH3)3 CBr OH (CH3)3 COH Br Vc[(CH3)CBr]一级反应Organic Chemistry Organic Chemistry Xiamen Xiamen University University R X + Nu R Nu + X N u c l e o p hilic sub stitu tio n R Br + NaOH R OH + NaBr CH 3Br + OH CH 3OH + Br V [C H 3 Br] [O H - ] (C H 3 ) 3CBr + OH (C H 3 ) 3COH + Br V [(C H 3 ) 3CBr ] 一级反应 二级反应