Two important pieces of information have been obtained about the nature of nucleophilic substitution reactions on E primary and secondary alkyl halides and tosy lates: a These reactions always occur with inversion of stereochemistry at the stereogenic carbon center a These reactions show second-order kinetics and follow the rate law: Rate= k [:Organic Chemistry Organic Chemistry Xiamen Xiamen University University Two important pieces of information have been obtained about the nature of nucleophilic substitution reactions on primary and secondary alkyl halides and tosylates: „ These reactions always occur with inversion of stereochemistry at the stereogenic carbon center. „ These reactions show second-order kinetics and follow the rate law: Rate = k [RX][Nu: - ]