v Section H- Target orientated drug design H1 Aims of drug design 141 H2 Computer aided drug design H3 Simplification of comple H4 Conformational restraint 151 H5 Extra binding interactions H6 Enhancing existing binding interactions Section I- Pharmacokinetic orientated drug design 167 I1 Section- Patenting and manufacture 177 J2 Optimization of reactions J3 Scale-up issues J4 Process devek 193 Section K-Preclinical testing and clinical trials 1 Toxicology K2 Pharmacology and pharmaceutical chemistry K3 Drug metabolism studies K4 Clinical trials 212 216 Section L-Case study: inhibitors of EGF-receptor kinase LI Epidermal growth factor receptor Testing pre 224 L3 From lead compound to dianilino-phthalimides A Modeling studies 5 4-(Phenylamino)pyrrolopyrimidine 239 6. Pyrazolopyrimidines 241 Section M - History of medicinal chemistry M1 The age of herbs, potions and magic M3 A fledgling science (1900-1930 M4 The dawn of the antibacterial age(1930-1945 M5 The antibiotic age (1945-1970s M6. The age of reason(1970s to present) Further reading Index