2018/3/27 Precision Medicine Precision Therapy EGFR mutation in tumor is a strong predictor of a better outcome with gefitinib. ◆ Precision Therapy he design of drugs that target specific pathogenic mutations ve the success of precision medicine Precision Medicine Complicated disease treatment che aeu d]ork cimes 加kgm healthy ceNs for comparison. And they found that Complicated disease treatment (FLT3) was wildly active in the How precision prediction might work Outline ◆ Heredity and Ge t Precision prediction and prevention Prevention and screening Precision prediction2018/3/27 4 Precision Medicine  Molecular diagnosis  Disease stratification  Precision Therapy The design of drugs that target specific pathogenic mutations may improve the success of precision medicine Mok, NEJM 2009 Precision Therapy Lung adenocarcinoma EGFR mutation in tumor is a strong predictor of a better outcome with gefitinib. Precision Medicine  Molecular diagnosis  Disease stratification  Precision Therapy  Complicated disease treatment In Washington University， Dr. Lukas Wartman had acute lymphoblastic leukemia (ALL). He was deteriorating fast. No known treatment could save him. Dr. Timothy Ley performed the DNA sequencing the RNA sequencing of both his cancer cells and healthy cells for comparison. And they found that a normal gene (FLT3) was wildly active in the leukemia cells. Even better, there was a new drug, that approved for treating advanced kidney cancer, could shut down the malfunctioning gene. Gene may be the primary factor in the treatment of cancer, not just on the basis of cancer tissue or organ itself. Complicated disease treatment How precision prediction might work？ Precision Medicine Precision Prediction Disease Outline Heredity and Gene Precision medicine Precision prediction and prevention The ethic of genetic testing